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Expression data from human 3D skin models treated with synthetic pseudo-ceramide for medical containing steroid cream

GSE253780 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/16 Platform GPL23934
Summary
Ceramides in the stratum corneum (SC) play an important role in the epidermal barrier function. We focused on these functions and developed a synthetic pseudo-ceramide for medical (SPCM)-containing steroid cream [SPCM (+)]. This cream forms films on the skin surface with multilamellar structures, like the human SC, and exerts anti-inflammatory effects through steroids. However, the preventive effects of this cream on disruption of skin barrier remain unclear. This study aimed to analyze the efficacy of SPCM (+) using human three-dimensional (3D) skin models.
Published in
Skin-Protective Performance of Alternative Stratum Corneum Formed by a Pseudo-Ceramide-Containing Steroid Lamellar Cream
Yokota M, Matsumoto T, Kawamoto A et al. · Experimental dermatology 2025 · PMID 40066914 · doi:10.1111/exd.70041
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Also filed as BioProject PRJNA1067121 and SRA study SRP484935. Searching any of these in the dataset finder brings you back here.

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