GEO series
RNA-Seq reveals heterogeneity in the submandibular glands and submandibular gland draining lymph nodes of SS mice
GSE253818
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/12/15
GPL24247
Summary
In this study, we analyzed the submandibular glands of P40-/-CD25+/- (control mice) and P40-/-CD25-/- (SS mice) after PD-1-targeted CAR-T cells or control T cells treatment using RNA-Seq. We found that the transcription of inflammatory genes was down-regulated and the transcription of tissue repair genes was up-regulated in the submandibular glands of SS mice after PD-1-targeted CAR-T cells treatment. In addition, PD-1+Tigit+CD8+ T cells in the submandibular gland draining lymph nodes of SS mice showed transcription characteristics of tissue resident memory precursors.
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Paper (PMID 40026078) ↗
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