RNA-Seq reveals heterogeneity in the submandibular glands and submandibular gland draining lymph nodes of SS mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Identification of Pathogenic PD-1(+)CD8(+) T Cells for Effective Chimeric Antigen Receptor Therapy in a Murine Model of Sjögren DiseaseArthritis & rheumatology (Hoboken, N.J.) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE253818_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1067327 and SRA study SRP485034. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 2 as controls.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8028307 control mice, salivary gland_1 [SG1]
- GSM8028308 control mice, salivary gland_2 [SG2]
- GSM8028309 Control T cell treated SS mice, salivary gland_1 [SG3]
- GSM8028310 Control T cell treated SS mice, salivary gland_2 [SG4]
- GSM8028311 CAR-T cell treated SS mice, salivary gland_1 [SG5]
- GSM8028312 CAR-T cell treated SS mice, salivary gland_2 [SG6]
- GSM8028313 SS mice, salivary gland draining lymph node, PD-1-Tigit-CD8+T cells_1 [dLN1 ]
- GSM8028314 SS mice, salivary gland draining lymph node, PD-1-Tigit-CD8+T cells_2 [dLN2]
- GSM8028315 SS mice, salivary gland draining lymph node, PD-1-Tigit-CD8+T cells_3 [dLN3]
- GSM8028316 SS mice, salivary gland draining lymph node, PD-1+Tigit+CD11+T cells_4 [dLN4]
- GSM8028317 SS mice, salivary gland draining lymph node, PD-1+Tigit+CD11+T cells_5 [dLN5]
- GSM8028318 SS mice, salivary gland draining lymph node, PD-1+Tigit+CD11+T cells_6 [dLN6]
- GSE333464 PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity 12 samples shares draining, lymph, nodes
- GSE318514 Organ injury in systemic autoimmunity is mediated by stem-like CD8 T cells arising from tissue-draining lymph nodes 45 samples shares draining, lymph, nodes
- GSE277228 Changing dynamics of the fibroblast differentiation hierarchy during mammary gland morphogenesis and tumorigenesis [scRNA-Seq I] 13 samples shares rna-seq, gland
- GSE308939 Single-cell RNA-seq reveals the keratinocyte heterogeneity and increased interfollicular basal keratinocytes in wound-induced hair follicle neogenesis 6 samples shares heterogeneity, rna-seq
- GSE281719 PD-1 Mediated Regulation of Unique Activated CD8+ T Cells by NK Cells in the Submandibular Gland [I15, I16] 60 samples shares submandibular, gland
- GSE292377 Step-wise signal integration governs adaptive programming of lymphocytes [bulkRNA-seq and ATAC-seq] 41 samples shares rna-seq, lymph
- GSE264105 Plate-based scRNA-seq of plasma-positive microglia and plasma-negative microglia in young mice 1111 samples shares rna-seq
- GSE277789 Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution [Smart-seq3-RNA-seq-add] 830 samples shares rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.