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Effect of disruption of IL-6 in cachectic C26 tumor on gene expression

GSE253861 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/10 Platform GPL24247
Summary
The IL-6 was reported as a key cachectic factor in mice inoculated with colon carcinoma 26 (C26) cells, a widely used cancer cachexia model. However, we identified We found that the growth of IL-6 KO tumors was dramatically delayed. More strikingly, while IL-6 KO tumors eventually reached the similar size as wild-type tumors, cachexia still took place, despite no elevation in circulating IL-6. We further showed that IL-6 promotes tumor growth by facilitating immune evatioon but is dispensable for cachexia.
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Also filed as BioProject PRJNA1063267 and SRA study SRP484093. Searching any of these in the dataset finder brings you back here.

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