PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [RNA-seq]
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcomaCell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE253892_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1067627 and SRA study SRP485240. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8029868 Control_RNAseq_mDOX_Rep1 Control_RNAseq_mDOX
- GSM8029869 Control_RNAseq_mDOX_Rep2 Control_RNAseq_mDOX
- GSM8029870 Control_RNAseq_mDOX_Rep3 Control_RNAseq_mDOX
- GSM8029871 P3F1_RNAseq_mDOX_Rep1 P3F1_RNAseq_mDOX
- GSM8029872 P3F1_RNAseq_mDOX_Rep2 P3F1_RNAseq_mDOX
- GSM8029873 P3F1_RNAseq_mDOX_Rep3 P3F1_RNAseq_mDOX
- GSM8029874 P7F1_RNAseq_mDOX_Rep1 P7F1_RNAseq_mDOX
- GSM8029875 P7F1_RNAseq_mDOX_Rep2 P7F1_RNAseq_mDOX
- GSM8029876 P7F1_RNAseq_mDOX_Rep3 P7F1_RNAseq_mDOX
- GSM8968583 Control_RNAseq_pDOX_Rep1 Control_RNAseq_pDOX
- GSM8968584 Control_RNAseq_pDOX_Rep2 Control_RNAseq_pDOX
- GSM8968585 Control_RNAseq_pDOX_Rep3 Control_RNAseq_pDOX
- GSM8968586 P3F1_RNAseq_pDOX_Rep1 P3F1_RNAseq_pDOX
- GSM8968587 P3F1_RNAseq_pDOX_Rep2 P3F1_RNAseq_pDOX
- GSM8968588 P3F1_RNAseq_pDOX_Rep3 P3F1_RNAseq_pDOX
- GSM8968589 P7F1_RNAseq_pDOX_Rep1 P7F1_RNAseq_pDOX
- GSM8968590 P7F1_RNAseq_pDOX_Rep2 P7F1_RNAseq_pDOX
- GSM8968591 P7F1_RNAseq_pDOX_Rep3 P7F1_RNAseq_pDOX
- GSE253893 PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [Cut&Run] 28 samples shares pax, rhabdomyosarcoma, translocations, mitochondrial, remodel, altered, leucine
- GSE297335 ABHD18 is essential for cardiolipin remodeling and its inhibition restores mitochondrial function in Barth Syndrome [RNA-Seq] 18 samples shares mitochondrial, remodel, rna-seq
- GSE279337 Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma 40 samples shares pax, rhabdomyosarcoma
- GSE279133 MYC plus class IIa HDAC inhibiton potentiates mitochondrial dysfunction in non-small cell lung cancer [RNA-seq] 64 samples shares mitochondrial, rna-seq
- GSE300974 CDK8 Inhibition Releases the Muscle Differentiation Blockade in Fusion-driven Alveolar Rhabdomyosarcoma [RNA-seq] 30 samples shares rhabdomyosarcoma, rna-seq
- GSE319937 Mitochondrial metabolism and epigenetic crosstalk drive the SASP (RNA-Seq_2) 18 samples shares mitochondrial, rna-seq
- GSE299462 REP-1 depletion causes altered mitochondrial energy metabolism in CHM disease, shifting from glycolysis to lipid oxidation 12 samples shares mitochondrial, altered
- GSE342354 Time-series RNA-seq of U2OS cells following CCCP-induced mitochondrial damage and recovery upon drug washout 12 samples shares mitochondrial, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.