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Effect of mitochondrial transfer from bone marrow stroma cells to anti-tumor T cells on T cell differentiation and function

GSE254191 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/09/13 Platform GPL30172
Summary
Mitochondrialloss and dysfunctiondrive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. We found that bone marrow stromal cells (BMSCs) transfer stromal cell mitochondria into CD8+ T cells. CD8+ T cells with donated mitochondria displayed enhanced mitochondrial respiration and spare respiratory capacity. When transferred into tumor-bearing hosts, these supercharged T cells expanded more robustly, infiltrated the tumor more efficiently, and exhibited fewer signs of exhaustion compared to T cells that did not take up mitochondria. As a result, mitochondria-boosted CD8+ T cells mediated superior antitumor responses, prolonging animal survival.
Published in
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
Baldwin JG, Heuser-Loy C, Saha T et al. · Cell 2024 · PMID 39276774 · doi:10.1016/j.cell.2024.08.029
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Also filed as BioProject PRJNA1068963 and SRA study SRP485890. Searching any of these in the dataset finder brings you back here.

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