Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 30 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 30 samples: 13 × HS68 Uninfected vs 13 × HS68 HCMV-infected vs 2 × ARPE-19 Uninfected vs 2 × ARPE-19 HCMV-infectedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activityeLife · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE254741_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1071598 and SRA study SRP487164. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 4 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8056975 ATAC-seq: HS68 Uninfected Replicate 1 HS68 Uninfected
- GSM8056976 ATAC-seq: HS68 Uninfected Replicate 2 HS68 Uninfected
- GSM8056977 ATAC-seq: HS68 HCMV-infected Replicate 1 HS68 HCMV-infected
- GSM8056978 ATAC-seq: HS68 HCMV-infected Replicate 2 HS68 HCMV-infected
- GSM8056979 ATAC-seq: ARPE-19 Uninfected Replicate 1 ARPE-19 Uninfected
- GSM8056980 ATAC-seq: ARPE-19 Uninfected Replicate 2 ARPE-19 Uninfected
- GSM8056981 ATAC-seq: ARPE-19 HCMV-infected Replicate 1 ARPE-19 HCMV-infected
- GSM8056982 ATAC-seq: ARPE-19 HCMV-infected Replicate 2 ARPE-19 HCMV-infected
- GSM8056983 RNA-seq: HS68 Uninfected Replicate 1 HS68 Uninfected
- GSM8056984 RNA-seq: HS68 Uninfected Replicate 2 HS68 Uninfected
- GSM8056985 RNA-seq: HS68 HCMV-infected Replicate 1 HS68 HCMV-infected
- GSM8056986 RNA-seq: HS68 HCMV-infected Replicate 2 HS68 HCMV-infected
- GSM8056987 H3K27ac ChIP-seq: HS68 Uninfected Replicate 1 HS68 Uninfected
- GSM8056988 H3K27ac ChIP-seq: HS68 Uninfected Replicate 2 HS68 Uninfected
- GSM8056989 H3K27ac ChIP-seq: HS68 HCMV-infected Replicate 1 HS68 HCMV-infected
- GSM8056990 H3K27ac ChIP-seq: HS68 HCMV-infected Replicate 2 HS68 HCMV-infected
- GSM8056991 CTCF ChIP-seq: HS68 Uninfected Replicate 1 HS68 Uninfected
- GSM8056992 CTCF ChIP-seq: HS68 Uninfected Replicate 2 HS68 Uninfected
- GSM8056993 CTCF ChIP-seq: HS68 HCMV-infected Replicate 1 HS68 HCMV-infected
- GSM8056994 CTCF ChIP-seq: HS68 HCMV-infected Replicate 2 HS68 HCMV-infected
- GSM8056995 TEAD1 ChIP-seq: HS68 Uninfected Replicate 1 HS68 Uninfected
- GSM8056996 TEAD1 ChIP-seq: HS68 Uninfected Replicate 2 HS68 Uninfected
- GSM8056997 TEAD1 ChIP-seq: HS68 HCMV-infected Replicate 1 HS68 HCMV-infected
- GSM8056998 TEAD1 ChIP-seq: HS68 HCMV-infected Replicate 2 HS68 HCMV-infected
- GSM8056999 H3K27ac HiChIP: HS68 Uninfected Replicate 1 HS68 Uninfected
- GSM8057000 H3K27ac HiChIP: HS68 Uninfected Replicate 2 HS68 Uninfected
- GSM8057001 H3K27ac HiChIP: HS68 Uninfected Replicate 3 HS68 Uninfected
- GSM8057002 H3K27ac HiChIP: HS68 HCMV-infected Replicate 1 HS68 HCMV-infected
- GSM8057003 H3K27ac HiChIP: HS68 HCMV-infected Replicate 2 HS68 HCMV-infected
- GSM8057004 H3K27ac HiChIP: HS68 HCMV-infected Replicate 3 HS68 HCMV-infected
- GSE196619 Synthetic transcription factor overrides persistent repressive chromatin marks 120 samples shares transcription, chromatin
- GSE296192 Hypoxic regulation of chromatin and gene transcription 98 samples shares transcription, chromatin
- GSE296190 Hypoxic regulation of chromatin and gene transcription [ChIP-seq] 84 samples shares transcription, chromatin
- GSE296831 Epigenetic Context Defines the Transcriptional Activity of Canonical and Noncanonical NF-kappaB Signaling in Pancreatic Cancer [ChIP-Seq] 48 samples shares transcription, activity
- GSE252883 Epiregulon: Inference of single-cell transcription factor activity to dissect mechanisms of lineage plasticity and drug response 38 samples shares transcription, activity
- GSE341599 CTCFL(BORIS) contributes to the transcriptional program of ovarian cancer by relaxing CTCF-mediated three-dimensional genome organization 32 samples shares transcription, organization
- GSE171817 SUMOylation Regulates Super-Enhancers Through Transcription Factor TFAP2C Binding on Chromatin 30 samples shares transcription, chromatin
- GSE227974 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells 29 samples shares transcription, activity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.