GEO series
Unraveling the mechanism of JPI-547 in human pancreatic cancer cells through transcriptome analysis.
GSE254997
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2025/02/28
GPL24676
Summary
This study aimed to elucidate the mechanism underlying the action of the dual PARP/Tankyrase inhibitor JPI-547 through RNA-sequencing. Focusing on human pancreatic cancer cell lines with either homologous recombination repair deficiency or Wnt-addiction, the investigation sought to uncover critical insights into the compound's mode of action.
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Paper (PMID 40959288) ↗
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