GEO series

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice

GSE255104 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/04/09 Platform GPL19057

Summary

Inhibitory neurons of the telencephalon are generated from progenitors in the ganglionic eminences that mature and differentiate into specialized cell types. Here, we used scRNA-seq and scATAC-seq together with lineage tracing and birthdating techniques to investigate the influence of neurogenesis timing on the development of GABAergic precursors. We found that the timing of neurogenesis substantially influences the progenitors' maturation competence (the capacity to develop toward a fully functional state), but not their differentiation competence (the ability to evolve into transcriptomically diverse states). The underlying mechanism was chromatin priming, orchestrated by the transcription factor Nfib in collaboration with regulators of inhibitory neuron development. Finally, the heterochronic transplantation of progenitors revealed an interplay between both intrinsic and extrinsic cues acting upon maturation competence. These findings identify a mechanism that coordinates inhibitory neuron development by changing their maturation to achieve maximum adaptability.

Published in

Bright AR, Kotlyarenko Y, Neuhaus F et al. · Nature neuroscience 2025 · PMID 40629142 · doi:10.1038/s41593-025-01999-y

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Direct links to NCBI, no account and no request form: the whole study as GSE255104_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1073526 and SRA study SRP488275. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40629142) ↗

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