GEO series
Paired CRISPR screens to map gene regulation in cis and trans (ATAC-seq)
GSE255698
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
27 samples
2024/11/28
GPL34281GPL18573
Summary
In this study, we develop a scalable approach that pairs discovery of cis- and trans-acting elements to systematically decipher the gene regulatory network. We explore the regulation of the immune checkpoint PD-L1 under both basal and IFNγ-stimulated contexts. PD-L1 expression on tumor cells serves as a clinically-actionable diagnostic for immune checkpoint blockade therapy across multiple cancer types.
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