Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 × Liver_control vs 8 × Liver_finasterideGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in menJournal of lipid research · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255708_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1076212 and SRA study SRP489586. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8078287 Liver_control_33 Liver_control
- GSM8078288 Liver_control_34 Liver_control
- GSM8078289 Liver_control_47 Liver_control
- GSM8078290 Liver_control_48 Liver_control
- GSM8078291 Liver_control_69 Liver_control
- GSM8078292 Liver_control_70 Liver_control
- GSM8078293 Liver_control_71 Liver_control
- GSM8078294 Liver_control_72 Liver_control
- GSM8078295 Liver_finasteride_25 Liver_finasteride
- GSM8078296 Liver_finasteride_26 Liver_finasteride
- GSM8078297 Liver_finasteride_40 Liver_finasteride
- GSM8078298 Liver_finasteride_41 Liver_finasteride
- GSM8078299 Liver_finasteride_61 Liver_finasteride
- GSM8078300 Liver_finasteride_63 Liver_finasteride
- GSM8078301 Liver_finasteride_64 Liver_finasteride
- GSM8078302 Liver_finasteride_65 Liver_finasteride
- GSE241770 ACSS2 mediates an epigenetic pathway to regulate maternal Beta-cell adaptation and progression of gestational diabetes (scRNA-Seq) 7899 samples shares progression
- GSE275176 Transcriptomic alterations associated with the progression of metabolic dysfunction-associated steatotic liver disease in CC042 Collaborative Cross mice. 60 samples shares progression
- GSE327470 Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System 292 samples shares progression
- GSE327468 Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – MADM-CloneSeq 287 samples shares progression
- GSE310017 Disease-associated mutations on the STAT5B SH2 domain regulate cholesterol and lipid metabolism in liver [RNA-Seq liver] 37 samples shares cholesterol
- GSE304692 Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH) [RNAseq_palmitate_silencing] 24 samples shares cholesterol
- GSE159911 “Bench-to-Bedside and Back” analysis of NAFLD model reveals common transcriptomic shifts between mouse and human during disease progression 152 samples shares progression
- GSE299709 Longitudinal monitoring of Type 1 Diabetes progression to disease onset 120 samples shares progression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.