MCF-7 ESR1 drug response
RNA-seq (gene expression) · human · 70 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 70 samples: 68 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255767_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1076486 and SRA study SRP489705. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 70 sample titles: 68 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8079112 LIB5440331_SAM24399127
- GSM8079113 LIB5440332_SAM24399128
- GSM8079114 LIB5440333_SAM24399129
- GSM8079115 LIB5440334_SAM24399130
- GSM8079116 LIB5440335_SAM24399131
- GSM8079117 LIB5440336_SAM24399132
- GSM8079118 LIB5440337_SAM24399133
- GSM8079119 LIB5440338_SAM24399134
- GSM8079120 LIB5440339_SAM24399135
- GSM8079121 LIB5440340_SAM24399136
- GSM8079122 LIB5440341_SAM24399137
- GSM8079123 LIB5440342_SAM24399138
- GSM8079124 LIB5440343_SAM24399139
- GSM8079125 LIB5440344_SAM24399140
- GSM8079126 LIB5440345_SAM24399141
- GSM8079127 LIB5440346_SAM24399142
- GSM8079128 LIB5440347_SAM24399143
- GSM8079129 LIB5440348_SAM24399144
- GSM8079130 LIB5440349_SAM24399145
- GSM8079131 LIB5440350_SAM24399146
- GSM8079132 LIB5440351_SAM24399147
- GSM8079133 LIB5440352_SAM24399148
- GSM8079134 LIB5440353_SAM24399149
- GSM8079135 LIB5440354_SAM24399150
- GSM8079136 LIB5440355_SAM24399151
- GSM8079137 LIB5440356_SAM24399152
- GSM8079138 LIB5440357_SAM24399153
- GSM8079139 LIB5440358_SAM24399154
- GSM8079140 LIB5440359_SAM24399155
- GSM8079141 LIB5440360_SAM24399156
- GSM8079142 LIB5440361_SAM24399157
- GSM8079143 LIB5440362_SAM24399158
- GSM8079144 LIB5440363_SAM24399159
- GSM8079145 LIB5440364_SAM24399160
- GSM8079146 LIB5440365_SAM24399161
- GSM8079147 LIB5440366_SAM24399162
- GSM8079148 LIB5440367_SAM24399163
- GSM8079149 LIB5440368_SAM24399164
- GSM8079150 LIB5440369_SAM24399165
- GSM8079151 LIB5440370_SAM24399166
+ 30 more — browse all 70 samples with per-sample file links →
- GSE255765 MCF-7 ESR1 drug response bulk RNA 64 samples shares mcf-7, esr1, drug
- GSE263089 ESR1 and p53 Interactome Defines Mechanisms of Therapeutic Response to Tamoxifen Therapy in Luminal Breast Cancer Patients 35 samples shares esr1
- GSE310672 Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation [RNA-seq] 48 samples shares esr1
- GSE324093 ESR1 mutations shape the clonal dynamics, genetic diversity and cellular states of acquired resistance to CDK4/6 inhibitors [RNA-seq] 32 samples shares esr1
- GSE246364 RNA-seq data for MCF-7 cells with ER knockdown or GDC-9545 treatment 14 samples shares mcf-7
- GSE221833 Next Generation Sequencing Analysis of Breast Cancer Cell Line MCF-7 And MDA-MB-231 After PI3K Inhibition 12 samples shares mcf-7
- GSE295509 Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape [ESR1_RNAseq] 12 samples shares esr1
- GSE246363 RNA-seq of MCF-7 cells with ER or FOXA1 knockout and/or GDC-9545 treatment 10 samples shares mcf-7
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.