The p21+ Perinecrotic Hepatocytes Produce the Chemokine Cxcl14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 10 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The p21(+) perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regenerationToxicology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255835_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1076645 and SRA study SRP489729. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 11 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8079900 Liver, explant, APAP
- GSM8079901 Liver, explant, Healthy_1
- GSM8079902 Liver, explant, Healthy_2
- GSM8081445 Control_48h_Hep
- GSM8081446 Control_48h_NPC
- GSM8081447 Control_72h_Hep
- GSM8081448 Control_72h_NPC
- GSM8081449 APAP_48h_Hep
- GSM8081450 APAP_48h_NPC
- GSM8081451 APAP_72h_Hep
- GSM8081452 APAP_72h_NPC
- GSE248947 Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration (RNA-Seq) 28 samples shares regeneration
- GSE302075 3D-printed nHA/PA66 porous scaffold: Regulating immune balance and vascularization synergistically promotes bone regeneration 24 samples shares regeneration
- GSE248948 Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration 170 samples shares regeneration
- GSE32606 Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection 46 samples shares regeneration
- GSE220722 Primary cilia as a targetable node between biliary injury, senescence and regeneration 12 samples shares regeneration
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.