Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [bulk RNA-seq]
RNA-seq (gene expression) · human · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 19 samples: 5 × 4 vs 5 × 4R_plus_K18 vs 5 × 4R_P301S vs 4 × 4R_P301S_plus_K18Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human iPSC 4R tauopathy model uncovers modifiers of tau propagationCell · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255902_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1076936 and SRA study SRP489930. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 4 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8082417 4R_1 4
- GSM8082418 4R_2 4
- GSM8082419 4R_3 4
- GSM8082420 4R_4 4
- GSM8082421 4R_5 4
- GSM8082422 4R_plus_K18_1 4R_plus_K18
- GSM8082423 4R_plus_K18_2 4R_plus_K18
- GSM8082424 4R_plus_K18_3 4R_plus_K18
- GSM8082425 4R_plus_K18_4 4R_plus_K18
- GSM8082426 4R_plus_K18_5 4R_plus_K18
- GSM8082427 4R_P301S_1 4R_P301S
- GSM8082428 4R_P301S_2 4R_P301S
- GSM8082429 4R_P301S_3 4R_P301S
- GSM8082430 4R_P301S_4 4R_P301S
- GSM8082431 4R_P301S_5 4R_P301S
- GSM8082432 4R_P301S_plus_K18_1 4R_P301S_plus_K18
- GSM8082433 4R_P301S_plus_K18_2 4R_P301S_plus_K18
- GSM8082434 4R_P301S_plus_K18_3 4R_P301S_plus_K18
- GSM8082435 4R_P301S_plus_K18_4 4R_P301S_plus_K18
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.