Whole transcriptome sequencing and circ_hsa_0001847 on proliferation and invasion of oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of malignant epithelial tumors in the oral and maxillofacial region, which is characterized by a high metastatic potential and an unfavorable prognosis. The specific process of oral mucosal carcinogenesis and progression is very complicated. We screened 2310 mRNAs differentially expressed in cancer and paraneoplastic tissues, of which 1019 were upregulated and 1291 were downregulated; 14216 differentially expressed lncRNAs, of which 8829 were upregulated and 5387 were downregulated; and 167 differentially expressed circRNAs, of which 18 were upregulated and 149 were downregulated. Oral squamous cell carcinoma cells had a higher level of hsa_circ_0001847 expression than hok cells (P<0.05). Reduced hsa_circ_0001847 expression inhibited oral squamous cell carcinoma cell proliferation, migration, and invasiveness (P<0.05). Oral tissues contain differentially expressed mRNAs, lncRNAs, and circRNAs, and these differentially expressed mRNAs, lncRNAs, and circRNAs may be involved in the development of OSCC.