Unfolded protein response is activated in leukocyte RNA from patients with severe heat stroke
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Leukocyte mRNA sequencing reveals unfolded protein response activation in severe heat stroke in JapanFrontiers in cell and developmental biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE256062_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1077969 and SRA study SRP490316. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 5 replicated groups read from 20 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8084846 HS1 HS
- GSM8084847 HS2 HS
- GSM8084848 HS3 HS
- GSM8084849 HS4 HS
- GSM8084850 HS5 HS
- GSM8084851 HS6 HS
- GSM8084852 HS7 HS
- GSM8084853 HC2 HC
- GSM8084854 HC3 HC
- GSM8084855 HC4 HC
- GSM8084856 HC5 HC
- GSM8084857 HC1_CP1
- GSM8084858 CP2 CP
- GSM8084859 CP3 CP
- GSM8084860 CM1 CM
- GSM8084861 CM2 CM
- GSM8084862 CM3 CM
- GSM8084863 CS1 CS
- GSM8084864 CS2 CS
- GSM8084865 CS3 CS
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- GSE285008 Transcriptome Response and Protein Abundance are Correlated with Split Formation and Cell Detachment as Secondary Effects to Autoantibodies in Human Skin Organ Culture Models for Pemphgus Vulgaris 78 samples shares protein
- GSE256237 The G3BP Stress-Granule Proteins Reinforce the Translation Program of the Integrated Stress Response 68 samples shares protein
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.