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YEATS4 Reads Histone Crotonylation to Promote Fatty Acid Metabolism and Cancer Cell Stemness [RNA-seq]

GSE256110 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/14 Platform GPL24676
Summary
How histone lysine crotonylation (Kcr) is read and interpreted remains to be elucidated. We report here that YEATS4, a potential breast cancer driver identified recently by two independent genome-wide association studies, is a reader of H3K14cr. Integrative metabolomic, epigenomic, and transcriptomic analyses reveal that H3K14cr reading by YEATS4 is associated with a shift of cellular metabolic profile and transcription activation of a cohort of genes, including CD36, CPT1A, and ACOX1, that are critically involved in the uptake and metabolism of fatty acids. High expression of YEATS4 fortifies fatty acid metabolism, enhances self-renewal and growth of ALDH+ breast cancer stem cells, and is correlated with poor prognosis of breast cancer patients, especially the ER+ subtype. Our work uncovers YEATS4 as an “amplifier” in the feedforward circuit of histone crotonylation and lipid metabolism underlying the stemness and cell proliferation, supporting the pursuit of YEATS4 as a potential target for breast cancer intervention.
Published in
YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
Peng Z, Yu H, Wang Y et al. · Cell reports 2025 · PMID 41060805 · doi:10.1016/j.celrep.2025.116400
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Also filed as BioProject PRJNA1078283 and SRA study SRP490431. Searching any of these in the dataset finder brings you back here.

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