Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer
RNA-seq (gene expression) · human · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 36 samples: 12 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Class IIa HDACs forced degradation allows resensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancerMolecular oncology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE256188_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1078384 and SRA study SRP490504. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 12 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8087320 FBXW7KO siCT OXPT 1 FBXW7KO siCT OXPT
- GSM8087321 FBXW7KO siCT OXPT 2 FBXW7KO siCT OXPT
- GSM8087322 FBXW7KO siCT OXPT 3 FBXW7KO siCT OXPT
- GSM8087323 FBXW7KO siCT UNT 1 FBXW7KO siCT UNT
- GSM8087324 FBXW7KO siCT UNT 2 FBXW7KO siCT UNT
- GSM8087325 FBXW7KO siCT UNT 3 FBXW7KO siCT UNT
- GSM8087326 FBXW7KO siHDAC4 OXPT 1 FBXW7KO siHDAC4 OXPT
- GSM8087327 FBXW7KO siHDAC4 OXPT 2 FBXW7KO siHDAC4 OXPT
- GSM8087328 FBXW7KO siHDAC4 OXPT 3 FBXW7KO siHDAC4 OXPT
- GSM8087329 FBXW7KO siHDAC4 UNT 1 FBXW7KO siHDAC4 UNT
- GSM8087330 FBXW7KO siHDAC4 UNT 2 FBXW7KO siHDAC4 UNT
- GSM8087331 FBXW7KO siHDAC4 UNT 3 FBXW7KO siHDAC4 UNT
- GSM8087332 KO PROTAC11 1 KO PROTAC11
- GSM8087333 KO PROTAC11 2 KO PROTAC11
- GSM8087334 KO PROTAC11 3 KO PROTAC11
- GSM8087335 KO PROTAC11 OXPT 1 KO PROTAC11 OXPT
- GSM8087336 KO PROTAC11 OXPT 2 KO PROTAC11 OXPT
- GSM8087337 KO PROTAC11 OXPT 3 KO PROTAC11 OXPT
- GSM8087338 WT PROTAC11 1 WT PROTAC11
- GSM8087339 WT PROTAC11 2 WT PROTAC11
- GSM8087340 WT PROTAC11 3 WT PROTAC11
- GSM8087341 WT PROTAC11 OXPT 1 WT PROTAC11 OXPT
- GSM8087342 WT PROTAC11 OXPT 2 WT PROTAC11 OXPT
- GSM8087343 WT PROTAC11 OXPT 3 WT PROTAC11 OXPT
- GSM8087344 WT siCT OXPT 1 WT siCT OXPT
- GSM8087345 WT siCT OXPT 2 WT siCT OXPT
- GSM8087346 WT siCT OXPT 3 WT siCT OXPT
- GSM8087347 WT siCT UNT 1 WT siCT UNT
- GSM8087348 WT siCT UNT 2 WT siCT UNT
- GSM8087349 WT siCT UNT 3 WT siCT UNT
- GSM8087350 WT siHDAC4 OXPT 1 WT siHDAC4 OXPT
- GSM8087351 WT siHDAC4 OXPT 2 WT siHDAC4 OXPT
- GSM8087352 WT siHDAC4 OXPT 3 WT siHDAC4 OXPT
- GSM8087353 WT siHDAC4 UNT 1 WT siHDAC4 UNT
- GSM8087354 WT siHDAC4 UNT 2 WT siHDAC4 UNT
- GSM8087355 WT siHDAC4 UNT 3 WT siHDAC4 UNT
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE256187 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer [ChIP-seq] 20 samples shares oxaliplatin-resistant, re-sensitization, super-enhancers, reorganization, fbxw7-mutated, colorectal, controls
- GSE270840 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer 10 samples shares oxaliplatin-resistant, re-sensitization, super-enhancers, reorganization, fbxw7-mutated, colorectal, controls
- GSE314768 Transcriptomic profiling of oxaliplatin-resistant colorectal cancer cells 6 samples shares oxaliplatin-resistant, colorectal
- GSE301359 Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [RNA-seq human] 9 samples shares reorganization, controls
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.