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Analysis of the effect of PSF on the gene expression profile in neuronal cells

GSE256401 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/19 Platform GPL24676
Summary
The multi-domain RNA-binding protein (RBP), polypyrimidine tract-binding protein (PTB)-associated splicing factor (PSF) or splicing factor, proline and glutamine-rich (SFPQ), regulate alternative splicing and transcriptional activation/repression by binding to the target RNA molecules. However, the gene regulatory mechanism of PSF in human neuronal cells is still unclear. We investigated the effect of PSF knockdown on the gene expression profile by RNA-seq using human neuronal cells, SH-SY5Y.
Published in
Cooperative nuclear action of RNA-binding proteins PSF and G3BP2 to sustain neuronal cell viability is decreased in aging and dementia
Takayama KI, Suzuki T, Sato K et al. · Aging cell 2024 · PMID 39155453 · doi:10.1111/acel.14316
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Also filed as BioProject PRJNA1079346 and SRA study SRP491111. Searching any of these in the dataset finder brings you back here.

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