GEO series
Innate immune responses are increased in children with acute asthma exacerbation
GSE256534
Homo sapiens
Expression profiling by high throughput sequencing
32 samples
2024/06/17
GPL24676
Summary
Our study aimed to better understand the immune responses during an acute asthma exacerbation in children. Gene expression profiles were examined by RNA-sequencing in blood samples. Samples were collected on average 2.5 day after systemic corticosteroid treatment. Our findings show that pro-inflammatory genes and pathways related to innate responses and signaling remained increased in children hospitalized for acute asthma exacerbation. Genes and pathways involved in adaptive immune respones, particularly T lymphocyte activation, were decreased in children hospitalized for acute asthma exacerbation. These studies suggest that innate immune responses may remain activated following hospitalization for asthma exacerbation.
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Paper (PMID 38873916) ↗
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