GEO series

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture

GSE25925 Homo sapiens Genome variation profiling by SNP array; SNP genotyping by SNP array 324 samples Submitted 2011/02/15 Platform GPL8882

Summary

Human embryonic and induced pluripotent stem cells (hESCs and iPSCs) are being considered as sources of differentiated cells for drug development and cell therapy. Genomic stability of these cells is important for in vitro studies, and is critical for clinical applications. Of particular concern for cell therapy is the known association between genetic aberrations and tumorigenicity. Our results highlight the dynamic nature of genomic abnormalities in pluripotent stem cell culture and the need for frequent genomic monitoring of pluripotent stem cells destined for transplantation in order to determine the impact of specific genomic changes on phenotypic stability and clinical safety.

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Direct links to NCBI, no account and no request form: the whole study as GSE25925_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 324 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA135725. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 21211785) ↗

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