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Effect of ablation of CEACAM1 on gene expression in human regulatory T cells

GSE259322 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/23 Platform GPL24676
Summary
To study the contribution of CEACAM1 in human Tregs, CEACAM1 was knocked out in ex-vivo expanded human Tregs by Crispr/Cas9. Tregs transfected with scramble gRNAs were used as controls. After electroporation, scramble or CEACAM1KO Tregs were subcultured with IL-2 for 7 days and RNA was isolated for genome-wide RNA-seq. Gene expression profiling analysis was performed using data obtained from RNA-seq of two replicates of CEACAM1KO and control cells.
Published in
BLIMP-1 and CEACAM1 cooperatively regulate human Treg homeostasis and function to control xenogeneic GVHD
Ding Y, Yu A, Vujanac M et al. · JCI insight 2025 · PMID 40773294 · doi:10.1172/jci.insight.183676
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Also filed as BioProject PRJNA1080673 and SRA study SRP491858. Searching any of these in the dataset finder brings you back here.

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