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ADRA2A is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer

GSE259390 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/06/28 Platform GPL30173
Summary
Pancreatic cancer is a heterogeneous disease and consists of distinct subtypes. Here, we investigated candidate suppressor genes of the basal-like/squamous subtype, a more aggressive molecular subtype of pancreatic ductal adenocarcinoma (PDAC). Through an integrated transcriptome analysis, we identified the ADRA2A, as being downregulated in the basal-like/squamous PDAC using a discovery and validation approach. ADRA2A downregulation is associated with decreased patient survival. The goal of this study was to identify ADRA2A-induced molecular signatures in PDAC.
Published in
ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
Moreno P, Ohara Y, Craig AJ et al. · bioRxiv : the preprint server for biology 2024 · PMID 38903083 · doi:10.1101/2024.03.12.584316
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Also filed as BioProject PRJNA1081404 and SRA study SRP492122. Searching any of these in the dataset finder brings you back here.

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