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Effect of glutamine treatment on human brain microvascular endothelial cells

GSE259423 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/01 Platform GPL24676
Summary
We found glutamine levels were positively associated with a greater risk of stroke. After treatment with glutamine, HBMECs exhibited enhanced proliferation, migration, and EndMT, all reversed by ITGB4 knockdown. In ITGB4-transfected HBMECs, the MAPK-ERK-TGF-β/BMP pathway was activated, with Smad4 knockdown reversing the EndMT. Furthermore, atorvastatin suppressed the EndMT by inhibiting Smad1/5 phosphorylation and promoting Smad4 ubiquitination in ITGB4-transfected HBMECs. Finally, ITGB4 upregulation was confirmed in the superficial temporal arteries of patients with moyamoya.
Published in
High glutamine increases stroke risk by inducing the endothelial-to-mesenchymal transition in moyamoya disease
He Q, Li J, Tao C et al. · MedComm 2024 · PMID 38628905 · doi:10.1002/mco2.525
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Also filed as BioProject PRJNA1081456 and SRA study SRP492143. Searching any of these in the dataset finder brings you back here.

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