GEO series
The effect of ORF57 knockout (KO) on host expression in iSLK/Bac16 cells.
GSE259446
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2024/11/21
GPL24676
Summary
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human oncogenic virus associated with various malignancies, including Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. The expression of viral products is essential for initiating and sustaining KSHV-induced tumors. KSHV ORF57, a viral RNA-binding protein, plays a crucial role in regulating viral gene expression at the posttranscriptional level by promoting viral RNA stability, splicing, and translation. In addition, ORF57 dysregulates host gene expression to promote viral replications.
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Paper (PMID 39655935) ↗
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