The effect of ORF57 knockout (KO) on host expression in iSLK/Bac16 cells.
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylationmBio · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE259446_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1081776 and SRA study SRP492270. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE302500 Effect of USP10 knockout using CRISPR on gene expression in MCF7 breast cancer cells 10 samples shares knockout
- GSE292720 Transcriptomic profiling of baricitinib effects on host immune response to RVFV infection in A549 cells and organoids 24 samples shares host
- GSE270946 Effect of IVNS1ABP mutation, knockout on gene expression during iPSCs differentiation to Neural Progenitors 18 samples shares knockout
- GSE309785 The impact of Tat expression on the host transcriptome landscape as the cells transit through the successive phases of the latency cycle 15 samples shares host
- GSE324345 Analysis of ER stress-induced three-dimensional enhancer network in wild-type and transcription facotr-knockout HCT116 cells [RNA-Seq] 66 samples shares knockout
- GSE327326 Hierarchical, non-additive MARTX effector interplay rewires host transcription to drive Vibrio vulnificus invasion and lethal sepsis 51 samples shares host
- GSE271378 Exploring host cellular responses to SARS-CoV-2 variants using RNA sequencing of infected human airway epithelial cells 44 samples shares host
- GSE295224 Dual single-cell and bulk RNA sequencing reveal transcriptional profiles underlying heterogenous host-parasite interactions in human peripheral blood mononuclear cells 42 samples shares host
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.