Exploring MicroRNA Patterns as Biomarkers of FOLFOX Chemotherapy-Induced Peripheral Neuropathy in Patients with Colorectal Cancer
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 16 samples: 7 × Plasma, FOLFOX 7 cycles & grade 2, Day0, sample vs 3 × Plasma, FOLFOX 2 cycles & grade 1, Day0, sample vs 3 × Plasma, FOLFOX 3 cycles & grade 1, Day0, sample vs 2 × Plasma, FOLFOX 3 cycles & grade 2, Day0, sampleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancerBiochimica et biophysica acta. Molecular basis of disease · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260661_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1082637 and SRA study SRP492792. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8121978 Plasma, FOLFOX 2 cycles & grade 1, Day0, sample 1 Plasma, FOLFOX 2 cycles…
- GSM8121979 Plasma, FOLFOX 3 cycles & grade 1, Day0, sample 2 Plasma, FOLFOX 3 cycles…
- GSM8121980 Plasma, FOLFOX 3 cycles & grade 1, Day0, sample 3 Plasma, FOLFOX 3 cycles…
- GSM8121981 Plasma, FOLFOX 2 cycles & grade 1, Day0, sample 4 Plasma, FOLFOX 2 cycles…
- GSM8121982 Plasma, FOLFOX 3 cycles & grade 2, Day0, sample 5 Plasma, FOLFOX 3 cycles…
- GSM8121983 Plasma, FOLFOX 3 cycles & grade 2, Day0, sample 6 Plasma, FOLFOX 3 cycles…
- GSM8121984 Plasma, FOLFOX 2 cycles & grade 1, Day0, sample 7 Plasma, FOLFOX 2 cycles…
- GSM8121985 Plasma, FOLFOX 3 cycles & grade 1, Day0, sample 8 Plasma, FOLFOX 3 cycles…
- GSM8121986 Plasma, FOLFOX 7 cycles & grade 3, Day0, sample 1
- GSM8121987 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 2 Plasma, FOLFOX 7 cycles…
- GSM8121988 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 3 Plasma, FOLFOX 7 cycles…
- GSM8121989 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 4 Plasma, FOLFOX 7 cycles…
- GSM8121990 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 5 Plasma, FOLFOX 7 cycles…
- GSM8121991 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 6 Plasma, FOLFOX 7 cycles…
- GSM8121992 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 7 Plasma, FOLFOX 7 cycles…
- GSM8121993 Plasma, FOLFOX 7 cycles & grade 2, Day0, sample 8 Plasma, FOLFOX 7 cycles…
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE330465 Gene expression profiling of neoadjuvant ABFOLFOX treatment in patients with unresectable colorectal cancer with liver metastases 104 samples shares folfox, colorectal
- GSE200407 RNA-seq between between FOLFOX chemotherapy sensitivity and insensitivity in colorectal cancer 22 samples shares folfox, colorectal
- GSE251778 Sex-specific and multiomic integration enhance accuracy of peripheral blood biomarkers of major depressive disorder [RNA-Seq] 169 samples shares biomarkers, peripheral
- GSE289582 Baseline tumor features and peripheral blood immune dynamics that underlie efficacy in MSS metastatic colorectal cancer treated with regorafenib, ipilimumab, and nivolumab [Blood] 115 samples shares peripheral, colorectal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.