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Structure and Dynamics of Enterovirus Genotype Networks

GSE260709 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/30 Platform GPL24676
Summary
Like all biological populations, viral populations exist as networks of genotypes connected through mutation. Mapping the topology of these networks and quantifying population dynamics across them is crucial to understanding how populations adapt to changes in their selective environment. The influence of mutational networks is especially profound in viral populations which rapidly explore their mutational neighborhoods via high mutation rates. Using a novel single-cell sequencing method, scRNAseq-Enabled Acquisition of mRNA and Consensus Haplotypes Linking Individual Genotypes and Host Transcriptomes (SEARCHLIGHT), we captured and assembled viral haplotypes from hundreds of individual infected cells to reveal the complexity of viral populations. We obtained these genotypes in parallel with host cell transcriptome information, enabling us to link host cell transcriptional phenotypes to the genetic structures underlying virus adaptation.
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Structure and dynamics of enterovirus genotype networks
Dábilla N, Dolan PT · Science advances 2024 · PMID 38896609 · doi:10.1126/sciadv.ado1693
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Also filed as BioProject PRJNA1082735 and SRA study SRP492860. Searching any of these in the dataset finder brings you back here.

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