GEO series
Gene expression profile of human mono-derived DCs stimulated with the bacterial lysate OM-85
GSE260787
Homo sapiens
Expression profiling by high throughput sequencing
45 samples
2024/03/11
GPL18573
Summary
OM-85 is a bacterial lysate used in clinical practice to reduce duration and frequency of recurrent respiratory tract infections. Whereas knowledge on its regulatory effects in vivo has substantially advanced, the mechanisms of OM-85 sensing remain inadequately addressed.The purpose of this study was to investigate the transptomic profile of human mo-DCs after ex vivo stimulation with OM-85 at determine to what extent OM-85-induced gene signature in different myeloid cell subsets is dependent on TLR2/TLR4 expression. We also aimed to compare the OM-85-triggered gene signature with the signatures induced by specific TLR2 or TLR4 agonists.
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Paper (PMID 38447907) ↗
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