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Transcriptomic analysis of co-culture generated lipid-associated macrophages (LAMs)

GSE260823 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/18 Platform GPL24676
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by profound remodeling of hepatic macrophages, including the emergence of lipid-associated macrophages (LAMs). However, the mechanisms through which LAMs promote fibrosis and their key molecular drivers remain elusive.
Published in
CD36-PPARγ-SPP1 axis mediates hepatocyte-macrophage coordination to drive MASLD-related liver fibrosis
Dai Z, Liu X, Liang Y et al. · JHEP reports : innovation in hepatology 2026 · PMID 41810434 · doi:10.1016/j.jhepr.2026.101745
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Also filed as BioProject PRJNA1083573 and SRA study SRP493271. Searching any of these in the dataset finder brings you back here.

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