Ancestral beta-globin gene haplotypes modify beta-thalassemia severity in a mouse model [Ery]
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse modelBlood advances · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260900_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1083954 and SRA study SRP493448. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8127722 A1_Single_Retic
- GSM8127723 A2_Single_EryA
- GSM8127724 A3_Single_EryB
- GSM8127725 A4_Diffuse_Retic
- GSM8127726 A5_Diffuse_EryA
- GSM8127727 A6_Diffuse_EryB
- GSM8127728 A7_Single_Retic
- GSM8127729 A8_Single_EryA
- GSM8127730 A9_Single_EryB
- GSM8127731 A10_Single_Retic
- GSM8127732 A11_Single_EryA
- GSM8127733 A12_Single_EryB
- GSM8127734 A13_Diffuse_Retic
- GSM8127735 A14_Diffuse_EryA
- GSM8127736 A15_Diffuse_EryB
- GSM8127737 A16_Diffuse_Retic
- GSM8127738 A17_Diffuse_EryA
- GSM8127739 A18_Diffuse_EryB
- GSM8127740 A19_Diffuse_Retic
- GSM8127741 A20_Diffuse_EryA
- GSM8127742 A21_Diffuse_EryB
- GSM8127743 A22_Single_Retic
- GSM8127744 A23_Single_EryA
- GSM8127745 A24_Single_EryB
- GSE260901 Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model [bone marrow, spleen] 40 samples shares haplotypes, ancestral, severity, modify
- GSE250266 EVOLUTIONARY CO-OPTION OF AN ANCESTRAL CLOACAL REGULATORY LANDSCAPE WITH THE EMERGENCE OF DIGITS AND GENITALS [RNA-seq] 12 samples shares ancestral
- GSE239477 Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution 72 samples shares ancestral
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.