GEO series
Revealing role of epigenetic modifers and DNA oxidation in cell‐autonomous regulation of Cancer stem cells
GSE260924
Homo sapiens
Expression profiling by high throughput sequencing
11 samples
2025/01/02
GPL18573
Summary
Breast cancer cells (BCCs) can remain undetected for decades in dormancy. These quiescent cells are similar to cancer stem cells (CSCs); hence their ability to initiate tertiary metastasis. Dormancy can be regulated by components of the tissue microenvironment such as bone marrow mesenchymal stem cells (MSCs) that release exosomes to dediferentiate BCCs into CSCs. The exosomes cargo includes histone 3, lysine 4 (H3K4) methyltransferases - KMT2B and KMT2D. A less studied mechanism of CSC maintenance is the process of cell-autonomous regulation, leading us to examine the roles for KMT2B and KMT2D in sustaining CSCs, and their potential as drug targets.
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Paper (PMID 38347590) ↗
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