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Single-cell transcriptomic analysis of mouse lung cDC2s at various times post allergic sensitization

GSE261034 Mus musculus Expression profiling by high throughput sequencing; Other 6 samples Submitted 2024/06/05 Platform GPL24247
Summary
Conventionaldendritic cells (cDCs) in the lung that drive effector T cell differentiation, and initiate allergic responses upon inhalation of allergens. CD11b+type 2 cDCs (cDC2s) are heterogeneous, but the relationship among subpopulations has been elusive. To analyze their developmental pathways of cDC2 subpopulations, we performed single cell RNA-sequencing (scRNAS-Seq) of total lung cDC2s at various times following inhalation of house dust extracts, and detected multiple clusters based on their differential transcriptomes. The data of cDC2 transcriptome at steady state, early and later stages after activation will be applicable for the maturation pathway analysis of cDC2s.
Published in
GM-CSF-dependent CD301b+ lung dendritic cells confer tolerance to inhaled allergens
Wilkinson CL, Nakano K, Grimm SA et al. · Research square 2024 · PMID 38883724 · doi:10.21203/rs.3.rs-4414130/v1
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Direct links to NCBI, no account and no request form: the whole study as GSE261034_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1084858 and SRA study SRP493724. Searching any of these in the dataset finder brings you back here.

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