Transcription factor 21 regulates cardiac myofibroblast formation and fibrosis [RNA-Seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 3 × In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - control vs 3 × In vivo cardiac fibroblasts from hearts with no injury - control vs 3 × In vivo cardiac fibroblasts from hearts with no injury - cardiac fibroblasts with loss of TCF21 vs 2 × In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - TCF21 overexpressoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and FibrosisCirculation research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261166_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1085669 and SRA study SRP494128. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 3 as controls.
How we read this: 4 replicated groups read from 16 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8136814 In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - control 1 In vivo cardiac fibrobl…
- GSM8136815 In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - control 2 In vivo cardiac fibrobl…
- GSM8136816 In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - control 3 In vivo cardiac fibrobl…
- GSM8136817 In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - TCF21 overexpressor 1 In vivo cardiac fibrobl…
- GSM8136818 In vivo cardiac fibroblasts from mice treated with angiotensin II/phenylephrine - TCF21 overexpressor 2 In vivo cardiac fibrobl…
- GSM8136819 In vivo cardiac fibroblasts from hearts with no injury - control 1 In vivo cardiac fibrobl…
- GSM8136820 In vivo cardiac fibroblasts from hearts with no injury - control 2 In vivo cardiac fibrobl…
- GSM8136821 In vivo cardiac fibroblasts from hearts with no injury - control 3 In vivo cardiac fibrobl…
- GSM8136822 In vivo cardiac fibroblasts from hearts with no injury - cardiac fibroblasts with loss of TCF21 1 In vivo cardiac fibrobl…
- GSM8136823 In vivo cardiac fibroblasts from hearts with no injury - cardiac fibroblasts with loss of TCF21 2 In vivo cardiac fibrobl…
- GSM8136824 In vivo cardiac fibroblasts from hearts with no injury - cardiac fibroblasts with loss of TCF21 3 In vivo cardiac fibrobl…
- GSM8502887 In vivo cardiac fibroblasts from mice treated with AII/phenylephrine - control 1 (T4770)
- GSM8502888 In vivo cardiac fibroblasts from mice treated with AII/phenylephrine - control 2 (T4780)
- GSM8502889 In vivo cardiac fibroblasts from mice treated with AII/phenylephrine - control 3 (T4835)
- GSM8502890 In vivo cardiac fibroblasts from mice treated with AII/phenylephrine - cardiac fibroblasts with loss of TCF21 1 (T4864)
- GSM8502891 In vivo cardiac fibroblasts from mice treated with AII/phenylephrine - cardiac fibroblasts with loss of TCF21 2 (T4867)
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- GSE286046 Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells 96 samples shares transcription, factor
- GSE282096 Diminished transcriptional activity and splicing changes drive gene length-biased rewiring in the aging transcriptome (RNA-Seq) 94 samples shares transcription, rna-seq
- GSE281037 Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells 48 samples shares transcription, factor
- GSE248585 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma (ssRNA-Seq) 46 samples shares transcription, rna-seq
- GSE245648 The Heme-regulated transcriptional repressor, BACH1 safeguards macrophage enhancer selection, activation andtissue adaptation [RNA-seq_BMDM] 24 samples shares transcription, rna-seq
- GSE264278 TIme-cource single-cell RNA-seq analysis of bleomycin and LPS-induced lung injury and fibrosis 18 samples shares fibrosis, rna-seq
- GSE215759 Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells [RNA-seq] 15 samples shares formation, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.