IL-10 Targets IRF1/5 to Suppress IFN and Inflammatory Responses by Epigenetic Mechanisms [RNA-Seq]
RNA-seq (gene expression) · human · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 30 samples: 10 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanismsNature immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261243_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1086153 and SRA study SRP494341. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 10 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8138631 RNA_IL10_Rep_1 RNA_IL10
- GSM8138632 RNA_IL10_Rep_2 RNA_IL10
- GSM8138633 RNA_IL10_Rep_3 RNA_IL10
- GSM8138634 RNA_IL10_LPS_Rep_1 RNA_IL10_LPS
- GSM8138635 RNA_IL10_LPS_Rep_2 RNA_IL10_LPS
- GSM8138636 RNA_IL10_LPS_Rep_3 RNA_IL10_LPS
- GSM8138637 RNA_LPS_Rep_1 RNA_LPS
- GSM8138638 RNA_LPS_Rep_2 RNA_LPS
- GSM8138639 RNA_LPS_Rep_3 RNA_LPS
- GSM8138640 RNA_Rest_Control_Rep_1 RNA_Rest_Control
- GSM8138641 RNA_Rest_Control_Rep_2 RNA_Rest_Control
- GSM8138642 RNA_Rest_Control_Rep_3 RNA_Rest_Control
- GSM8138643 RNA_LPS_HPRT_Rep_1 RNA_LPS_HPRT
- GSM8138644 RNA_LPS_HPRT_Rep_2 RNA_LPS_HPRT
- GSM8138645 RNA_LPS_HPRT_Rep_3 RNA_LPS_HPRT
- GSM8138646 RNA_LPS_IRF1_5_DKO_Rep_1 RNA_LPS_IRF1_5_DKO
- GSM8138647 RNA_LPS_IRF1_5_DKO_Rep_2 RNA_LPS_IRF1_5_DKO
- GSM8138648 RNA_LPS_IRF1_5_DKO_Rep_3 RNA_LPS_IRF1_5_DKO
- GSM8138649 RNA_IL-10_Donor1 RNA_IL-10_Dono
- GSM8138650 RNA_IL-10_Donor2 RNA_IL-10_Dono
- GSM8138651 RNA_IL-10_Donor3 RNA_IL-10_Dono
- GSM8138652 RNA_IL-10+TNF_Donor1 RNA_IL-10+TNF_Dono
- GSM8138653 RNA_IL-10+TNF_Donor2 RNA_IL-10+TNF_Dono
- GSM8138654 RNA_IL-10+TNF_Donor3 RNA_IL-10+TNF_Dono
- GSM8138655 RNA_Resting_control_Donor1 RNA_Resting_control_Dono
- GSM8138656 RNA_Resting_control_Donor2 RNA_Resting_control_Dono
- GSM8138657 RNA_Resting_control_Donor3 RNA_Resting_control_Dono
- GSM8138658 RNA_TNF_Donor1 RNA_TNF_Dono
- GSM8138659 RNA_TNF_Donor2 RNA_TNF_Dono
- GSM8138660 RNA_TNF_Donor3 RNA_TNF_Dono
- GSE290418 Bulk RNA-sequencing of human non-IBD enteroids treated with interferon-gamma (IFNγ) 12 samples shares ifn, rna-seq
- GSE284217 Bacterial immunotherapy leveraging IL-10R hysteresis for both phagocytosis evasion and tumor immunity revitalization [RNA-Seq] 12 samples shares il-10, rna-seq
- GSE282444 Epigenetic Memory of Intestinal Epithelial Cells in Inflammatory Bowel Disease [RNA-seq] 56 samples shares epigenetic, rna-seq
- GSE294916 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [CUT&Tag] 28 samples shares ifn, epigenetic
- GSE234181 Long-term multi-modal recording reveals epigenetic adaptation routes in dormant breast cancer cells [scRNA-Seq] 184 samples shares epigenetic, rna-seq
- GSE232076 In vitro reconstitution of epigenetic reprogramming in the human germ line [RNA-Seq] 89 samples shares epigenetic, rna-seq
- GSE306915 Integrated epigenetic and genetic programming of primary human T cells [RNA-seq] 77 samples shares epigenetic, rna-seq
- GSE248728 BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow (scRNA-Seq) 28 samples shares epigenetic, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.