Inflammation of the Nasal Mucosa is Associated with Susceptibility to Experimental Pneumococcal Challenge in Older Adults
RNA-seq (gene expression) · human · 115 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 115 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adultsMucosal immunology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261277_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1086376. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 115 more — browse all 115 samples with per-sample file links →
- GSE271128 Intraesophageally challenge of OVA to epicutaneously sensitized mice with loss of epithelial Ikkβ results in experimental EoE that is faithful to human EoE esophageal mucosal pathology. 54 samples shares experimental, challenge, mucosa
- GSE310241 Mucosal inflammation and pre-existing antibodies define protection and disease outcomes in human Bordetella pertussis challenge 414 samples shares challenge, mucosa
- GSE155237 RNAseq of nasal cells from pre-symptomatic volunteers experimentally infected with RSV 78 samples shares experimental, nasal
- GSE296893 Persistent pneumococcal colonisation in anti-retroviral-treated HIV infection is associated with nasal inflammation 11 samples shares pneumococcal, nasal
- GSE301133 Lung mucosal and systemic responses at single-cell resolution in an aerosolised Mycobacterium bovis BCG human challenge model 159 samples shares challenge, mucosa
- GSE325674 Leveraging experimental evolution to extract predictive collateral drug response signatures in Ewings Sarcoma 73 samples shares experimental
- GSE250241 Allergen Challenge for Evoked Phenotypes in Asthma (the ACE Study) 66 samples shares challenge
- GSE310965 Islet-Intrinsic Sex Differences in Inflammatory Signaling Contribute to Autoimmune Diabetes Susceptibility 60 samples shares susceptibility
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.