GEO series
Direct measurement of RNA Polymerase II hypertranscription in cancer FFPE samples
GSE261351
Homo sapiens; Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
278 samples
2025/01/16
GPL30173GPL11154GPL30172
Summary
Hypertranscription occurs at targets of oncogene transcription factors in aggressive human cancers. However, detection relies on mRNAs which are heavily processed and have variable half-lives, and on accurate cell number estimations. Here we apply FFPE-CUTAC on slides and curls to quantify hypertranscription at regulatory elements and replication-coupled histone genes.
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NCBI GEO page ↗
Paper (PMID 39946483) ↗
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