GEO series
Alternative splicing events driven by altered levels of Gemin5 undergo translation
GSE261488
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2024/08/19
GPL24676
Summary
We show that upregulation of Gemin5 can be detrimental as it modifies the steady state of mRNAs and enhances alternative splicing (AS) events of genes involved in a broad range of cellular processes. RNA-Seq analyses of the mRNA associated with polysomes in cells with high levels of Gemin5 revealed that a significant fraction of the differential AS events was enriched in polysomes.
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Paper (PMID 39194147) ↗
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