GEO series
Pim1 exacerbates inflammatory arthritis by mediating Th17 differentiation
GSE261671
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/03/04
GPL23227
Summary
The present study demonstrated that pim1-promoted mito-Ca2+ influx enhanced the activity of mitochondrial OXPHOS, bringing about the differentiation of Th17 and driving the pathogenic progression of inflammatory arthritis. Targeting pim1 impeded Th17 differentiation and alleviated collagen-induced arthritis (CIA) and SKG arthritis, suggesting that Pim1 is a target for the treatment of inflammatory arthritis.
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Paper (PMID 41767599) ↗
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