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PAR-CLIP analysis of neuroblastoma cells in response to amidino-rocaglate treatment

GSE261761 Homo sapiens Expression profiling by high throughput sequencing; Other 8 samples Submitted 2024/06/25 Platform GPL24676
Summary
MYCN-amplified neuroblastoma cells exhibit upregulation of translation initiation factors as a result of MYCN-driven transcriptional amplification, including the RNA helicase eIF4A1. Here, we treated MYCN-amplified patient derived xenograft (PDX) neuroblastoma cells with a novel translation initiation inhibitor, amidino-rocaglate CMLD12824, to analyze the impact on the global pattern of eIF4A1 binding to mRNA compared to the naive condition.
Published in
The MYCN 5' UTR as a therapeutic target in neuroblastoma
Volegova MP, Brown LE, Banerjee U et al. · Cell reports 2024 · PMID 38662542 · doi:10.1016/j.celrep.2024.114134
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Also filed as BioProject PRJNA1088607 and SRA study SRP495547. Searching any of these in the dataset finder brings you back here.

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