Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration
RNA-seq (gene expression) · human · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 17 samples: 17 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regenerationNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261794_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1089084 and SRA study SRP408797. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 1 as controls.
How we read this: Read from 17 sample titles: 17 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6744045 HPEpiC, Untreated, Biol rep1, Tube1
- GSM6744046 HPEpiC, TGFβ1-treated, Biol rep1, Tube1
- GSM6744047 HPEpiC, IL11-treated, Biol rep1, Tube1
- GSM6744048 HPEpiC, Untreated, Biol rep2, Tube2
- GSM6744049 HPEpiC, TGFβ1-treated, Biol rep2, Tube2
- GSM6744050 HPEpiC, IL11-treated, Biol rep2, Tube2
- GSM6744051 HPEpiC, Untreated, Biol rep3, Tube3
- GSM6744052 HPEpiC, TGFβ1-treated, Biol rep3, Tube3
- GSM6744053 HPEpiC, IL11-treated, Biol rep3, Tube3
- GSM6744054 HPEpiC, Untreated, Biol rep4, Tube4
- GSM6744055 HPEpiC, TGFβ1-treated, Biol rep4, Tube4
- GSM6744056 HPEpiC, IL11-treated, Biol rep4, Tube4
- GSM6744057 HPEpiC, Untreated, Biol rep5, Tube4
- GSM8152114 Lung,KO,blm
- GSM8152115 Lung,KO, WT ,saline
- GSM8152116 Lung,WT,blm
- GSM8152117 Lung,WT,saline
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples shares dysfunction
- GSE227075 Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells [scRNA-seq] 22 samples shares regeneration
- GSE342640 Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation 159 samples shares dysfunction
- GSE294342 ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis 20 samples shares regeneration
- GSE282283 YAP activation reverses aging-related visual dysfunction caused by impaired cell-matrix adhesion 15 samples shares dysfunction
- GSE303466 CD24+ human dental papilla cells as translational seed cells for dentin-pulp regeneration via BMP2/SIRT1 metabolic axis 12 samples shares regeneration
- GSE271871 A leiomodin 2 neonatal dilated cardiomyopathy causing mutation results inaltered actin-regulatory gene signatures andcardiomyocyte dysfunction 42 samples shares dysfunction
- GSE292577 Aspiration-assisted intra-operative 3D bioprinting of scaffold-free modular units for skeletal muscle tissue regeneration 39 samples shares regeneration
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.