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Human-Specific Elimination of Epithelial Siglec-XII Suppresses the Risk of CRC Initiation and Progression [CACO]

GSE262085 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/27 Platform GPL24676
Summary
Human-specific changes in specific Siglecs is one of the reasons put forth as molecular mechanisms that could explain human proneness to developing cancers. The SIGLEC12 gene, which encodes the Siglec-XII protein mainly found on epithelial cells, has a fixed homozygous missense mutation in a critical arginine renders unable to recognize its natural ligand. Additionally, the gene harbors a polymorphic frameshift mutation that eliminates expression of the full-length protein in most humans. We hypothesized that dysfunctional Siglec-XII is involved in cancer progression in humans' epithelia. Here we report that the forced expression of human Siglec-XII in caco-2 cells showed that differentially expressed genes in Siglec-XII cells were enriched for diverse bioenergetic processes.
Published in
Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers
Cuello HA, Sinha S, Verhagen AL et al. · JCI insight 2024 · PMID 38990656 · doi:10.1172/jci.insight.181539
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Also filed as BioProject PRJNA1090164 and SRA study SRP496775. Searching any of these in the dataset finder brings you back here.

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