GEO series
Remodeling of Histone lactylation, acetylation, and methylation in circulating monocytes by BCG vaccination
GSE262096
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
33 samples
2025/04/30
GPL18573
Summary
The innate immune system can develop memory-like features, recalling past infections or vaccinations and enabling more efficient responses to future threats, a process known as trained immunity (cite). Trained innate immune cells triggered by various microbial components or vaccines such as Bacille Calmette-Guérin (BCG), can confer broad-spectrum, heterologous (non-specific) protection against diverse pathogens. Subjects were vaccinated in with BCG vaccine and lood samples were obtained immediately before BCG vaccination (day 0) and subsequently on day 14 and day 90 post-vaccination
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