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Single-cell multiome of human RPE and choroid

GSE262151 Homo sapiens (human) Single-cell RNA-seq 33 samples Submitted 2025/03/25 Platform GPL24676Platform GPL21697
At a glance

Single-cell RNA-seq · human · 33 samples

What it is
Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
Organism
Homo sapiens (human)
Samples
33 samples: 16 × Human RPE/choroid scATAC vs 16 × Human RPE/choroid scRNAGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degenerationCell reports · 2026
Summary (written by the submitters)
We present a joint scRNA-seq and scATAC-seq atlas of adult human retinal pigment epithelium (RPE) and choroid. We integrate this atlas with a HiChIP enhancer connectome to predict noncoding variants with causal roles in age-related macular degeneration (AMD).
Published in
Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration
Wang SK, Li J, Nair S et al. · Cell reports 2026 · PMID 41528844 · doi:10.1016/j.celrep.2025.116814
This dataset
Open GSE262151 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262151_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.

Also filed as BioProject PRJNA1090480 and SRA study SRP497013. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41528844) ↗
Study design
16 × Human RPE/choroid scATAC vs 16 × Human RPE/choroid scRNA

Supports a between-group comparison across 32 samples.

How we read this: 2 replicated groups read from 33 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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