MEG3 Upregulation in Myotonic Dystrophy and Its Correction by Antisense Conjugates Targeting Disease-Causing Mutations [mRNA-seq]
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262163_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1090497 and SRA study SRP497042. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8158991 DM1 myotube, cytoplasm fraction, cell culture 1, replicate 1 (mRNAseq)
- GSM8158992 DM1 myotube, cytoplasm fraction, cell culture 1, replicate 2 (mRNAseq)
- GSM8158993 DM1 myotube, cytoplasm fraction, cell culture 1, replicate 3 (mRNAseq)
- GSM8158994 DM1 myotube, cytoplasm fraction, cell culture 2, replicate 1 (mRNAseq)
- GSM8158995 DM1 myotube, cytoplasm fraction, cell culture 2, replicate 2 (mRNAseq)
- GSM8158996 DM1 myotube, cytoplasm fraction, cell culture 2, replicate 3 (mRNAseq)
- GSM8158997 DM1 myotube, nucleus fraction, cell culture 1, replicate 1 (mRNAseq)
- GSM8158998 DM1 myotube, nucleus fraction, cell culture 1, replicate 2 (mRNAseq)
- GSM8158999 DM1 myotube, nucleus fraction, cell culture 1, replicate 3 (mRNAseq)
- GSM8159000 DM1 myotube, nucleus fraction, cell culture 2, replicate 1 (mRNAseq)
- GSM8159001 DM1 myotube, nucleus fraction, cell culture 2, replicate 2 (mRNAseq)
- GSM8159002 DM1 myotube, nucleus fraction, cell culture 2, replicate 3 (mRNAseq)
- GSM8159003 WT myotube, cytoplasm fraction, cell culture 3, replicate 1 (mRNAseq)
- GSM8159004 WT myotube, cytoplasm fraction, cell culture 3, replicate 2 (mRNAseq)
- GSM8159005 WT myotube, cytoplasm fraction, cell culture 3, replicate 3 (mRNAseq)
- GSM8159006 WT myotube, cytoplasm fraction, cell culture 4, replicate 1 (mRNAseq)
- GSM8159007 WT myotube, cytoplasm fraction, cell culture 4, replicate 2 (mRNAseq)
- GSM8159008 WT myotube, cytoplasm fraction, cell culture 4, replicate 3 (mRNAseq)
- GSM8159009 WT myotube, nucleus fraction, cell culture 3, replicate 1 (mRNAseq)
- GSM8159010 WT myotube, nucleus fraction, cell culture 3, replicate 2 (mRNAseq)
- GSM8159011 WT myotube, nucleus fraction, cell culture 3, replicate 3 (mRNAseq)
- GSM8159012 WT myotube, nucleus fraction, cell culture 4, replicate 1 (mRNAseq)
- GSM8159013 WT myotube, nucleus fraction, cell culture 4, replicate 2 (mRNAseq)
- GSM8159014 WT myotube, nucleus fraction, cell culture 4, replicate 3 (mRNAseq)
- GSE316609 Upregulation of the lncRNA MEG3 in Metastatic Hepatoblastoma 4 samples shares meg3, upregulation
- GSE253830 Long non-coding RNA MEG3 promotes angiogenesis by directly regulating integrin signaling impairing endothelial cell function 7 samples shares meg3
- GSE242536 Effect of overexpression of MEG3 on gene expression in prostate cancer lncap cells 6 samples shares meg3
- GSE315495 SARS-CoV-2 spike protein exerts an anti-cancer effect by regulating MEG3 and BCYRN1 in A549 cells 4 samples shares meg3
- GSE298461 MEG3 Prevents Cell Death by Restoring Autophagic Flux in Developing Neurons with CLCN4 Variants 4 samples shares meg3
- GSE234544 Long Non-Coding RNA MEG3 Promotes Angiogenesis by directly regulating integrin signaling impairing endothelial cell function. 14 samples shares meg3
- GSE234543 Long Non-Coding RNA MEG3 Promotes Angiogenesis by directly regulating integrin signaling impairing endothelial cell function [ChIP-seq] 6 samples shares meg3
- GSE241326 Possible involvement of a MEG3-miR-21-SPRY1-NF-kB feedback loop in spermatogenic cells proliferation, autophagy and apoptosis 6 samples shares meg3
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.