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Single cell transcriptomic profile of splenic B and T cells from B-cell specific Il2rb deficient mice

GSE262465 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/27 Platform GPL24247
Summary
IL-2 is one of the first cytokine discovered but its complex roles in T cell effector functions has shadowed its function in B cell responses. B cells transiently expressed IL-2 receptor upon activation but it is unclear whether all mature B cell subsets have an equal dependence upon IL-2 and how IL-2 dictates B cell fate. Using our newly generated B-cell-specific Il2rb conditional knockout (KO) model of mice lacking IL2RB signaling in mature B cells, our objectives were to characterize the heterogeneity of splenic B cell early response to in vivo immunization (SRBC) comparing scRNAseq data from control and KO mice. In parallel, we analyzed T cell subsets.
Published in
B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25(+) age-associated B cells
Gauthier J, Maugendre M, Léonard S et al. · Immunity 2026 · PMID 41619728 · doi:10.1016/j.immuni.2026.01.015
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Also filed as BioProject PRJNA1091932 and SRA study SRP497874. Searching any of these in the dataset finder brings you back here.

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