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Targeted bisulfite sequencing in PTC [ATAC-Seq]

GSE262493 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/05/14 Platform GPL16791
Summary
This study illuminates the critical advancement in the personalized management of papillary thyroid cancer (PTC) through the identification and validation of epigenetic biomarkers. We discovered the two distinct PTC subgroups with varying prognoses through TBS and observed the clues that PTC1 may related to immune signatures through multi-omics sequencing analysis. Then, we introduce FNAB, a minimally invasive preoperative test, for prognostication and therapeutic decision-making. Utilizing FNAB coupled with real-time digital PCR, our methodology not only facilitates the sensitive detection of seven pivotal biomarkers, but also integrates seamlessly with the established TNM staging system to significantly refine survival predictions. This approach heralds a new era in the precise, personalized treatment of PTC, promising improved patient outcomes through the strategic application of epigenetic insights in clinical practice.
Published in
Epigenomic profiling of papillary thyroid carcinoma reveals distinct subtypes with clinical implications
Lee Y, Park HJ, Lee JS et al. · NPJ precision oncology 2025 · PMID 40348904 · doi:10.1038/s41698-025-00932-7
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Direct links to NCBI, no account and no request form: the whole study as GSE262493_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1092043 and SRA study SRP497912. Searching any of these in the dataset finder brings you back here.

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