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The differential gene expression of the lung cancer cell line HCC827 before and after resistance to osimertinib

GSE262582 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/30 Platform GPL24676
Summary
Osimertinib, as a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), has been approved as a first-line therapy in advanced non–small-cell lung cancer (NSCLC) patients with EGFR-activating or T790M resistance mutations. However, the efficacy of osimertinib is limited due to acquired resistance. In order to search for the mechanism of resistance to osimertinib, we screened on significantly upregulated genes encoding protein kinases in osimertinib-resistant NSCLC cells via RNA-sequence.In summary, our data elucidate the alterations in gene expression within lung cancer cells before and after resistance to osimertinib, aiding in the analysis and identification of key molecules influencing osimertinib resistance.
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Direct links to NCBI, no account and no request form: the whole study as GSE262582_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1092593 and SRA study SRP498125. Searching any of these in the dataset finder brings you back here.

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