GEO series
Effect of ATRA on HH, Hut78 and NB4 cells
GSE262586
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/04/01
GPL23227
Summary
Cutaneous T-cell lymphoma (CTCL) is a highly heterogeneous non-Hodgkin lymphoma.While retinoids analog including ATRA have been used to treat CTCLs for decades, their mechanism of action and the role of RA-RARα signaling remain poorly understood.Thus,we treated CTCL cells with ATRA.In parallel, we treated acute promyelocytic leukemia (APL) cell line NB4 with ATRA followed by RNA-seq analysis.Total RNA was prepared from biological duplicate plates of cells and subjected to bulk RNAseq. 150-bp paired-end sequencing was performed on the BGISEQ-500.
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Paper (PMID 39632829) ↗
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