SCD1-dependant activation of GSK3β-NRF2-SLC7A11 pathway regulates lipid metabolism and suppresses ferroptosis in KRAS/STK11/KEAP1 co-mutant lung adenocarcinoma
RNA-seq (gene expression) · human · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 36 samples: 36 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung AdenocarcinomaCancer research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262660_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1092743 and SRA study SRP498316. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 36 sample titles: 36 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8173216 Sample 1_Rep1_H661 Control
- GSM8173217 Sample 1_Rep2_H661 Control
- GSM8173218 Sample 1_Rep3_H661 Control
- GSM8173219 Sample 2_Rep1_H661 CVT-11127 Treatment
- GSM8173220 Sample 2_Rep2_H661 CVT-11127 Treatment
- GSM8173221 Sample 2_Rep3_H661 CVT-11127 Treatment
- GSM8173222 Sample 3_Rep1_H358 Control
- GSM8173223 Sample 3_Rep2_H358 Control
- GSM8173224 Sample 3_Rep3_H358 Control
- GSM8173225 Sample 4_Rep1_H358 CVT-11127 Treatment
- GSM8173226 Sample 4_Rep2_H358 CVT-11127 Treatment
- GSM8173227 Sample 4_Rep3_H358 CVT-11127 Treatment
- GSM8173228 Sample 5_Rep1_H1993 Control
- GSM8173229 Sample 5_Rep2_H1993 Control
- GSM8173230 Sample 5_Rep3_H1993 Control
- GSM8173231 Sample 6_Rep1_H1993 CVT-11127 Treatment
- GSM8173232 Sample 6_Rep2_H1993 CVT-11127 Treatment
- GSM8173233 Sample 6_Rep3_H1993 CVT-11127 Treatment
- GSM8173234 Sample 7_Rep1_H2228 Control
- GSM8173235 Sample 7_Rep2_H2228 Control
- GSM8173236 Sample 7_Rep3_H2228 Control
- GSM8173237 Sample 8_Rep1_H2228 CVT-11127 Treatment
- GSM8173238 Sample 8_Rep2_H2228 CVT-11127 Treatment
- GSM8173239 Sample 8_Rep3_H2228 CVT-11127 Treatment
- GSM8173240 Sample 9_Rep1_H2122 Control
- GSM8173241 Sample 9_Rep2_H2122 Control
- GSM8173242 Sample 9_Rep3_H2122 Control
- GSM8173243 Sample 10_Rep1_H2122 CVT-11127 Treatment
- GSM8173244 Sample 10_Rep2_H2122 CVT-11127 Treatment
- GSM8173245 Sample 10_Rep3_H2122 CVT-11127 Treatment
- GSM8173246 Sample 9_Rep1_H460 Control
- GSM8173247 Sample 9_Rep2_H460 Control
- GSM8173248 Sample 9_Rep3_H460 Control
- GSM8173249 Sample 10_Rep1_H460 CVT-11127 Treatment
- GSM8173250 Sample 10_Rep2_H460 CVT-11127 Treatment
- GSM8173251 Sample 10_Rep3_H460 CVT-11127 Treatment
- GSE104244 Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents 33 samples same disease briefing · shares kras
- GSE27389 Substitutions in the KRas oncogene determine protein behavior: Implications for signaling and clinical outcome. 22 samples same disease briefing · shares kras
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples same disease briefing · shares adenocarcinoma
- GSE127465 Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species 40 samples same disease briefing
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples same disease briefing
- GSE117570 Reprogramming of Tumor-infiltrating Immune Cells in Early Stage of NSCLC 8 samples same disease briefing
- GSE241518 High-throughout sequencing of colorectal cancer and non-small cell lung cancer cells treated actived compound YHM18 4 samples same disease briefing
- GSE17958 Affymetrix SNP array data for 47 lung squamous cell carcinoma and 40 esophageal squamous cell carcinoma samples. 87 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.