GEO series
Systemic comparison of molecular characteristics in different skin fibroblast senescent models
GSE262932
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2024/04/10
GPL24676
Summary
Each senescent FB model exhibited different characteristics. Besides the upregulated expression of natural senescence features, FB-UVB and FB-ATV expressed high levels of senescence-related genes including SASP, and FB-P30 had the greatest similarity with FB-E. However, D-galactose-stimulated FB did not clearly present aging characteristics. It provides references for choosing senescent FB model in studying aging and related skin disease.
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Paper (PMID 39329281) ↗
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