Elucidating the role of RXR in driving the OnF porgram along the CRC malignancy contiuum.
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancerNature genetics · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263045_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1095507 and SRA study SRP499370. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE263044 Transcriptional profiling of advanced CRC tumoroids (AKSP) follwoing RXR inhbition 6 samples shares rxr, crc
- GSE280300 Vhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [bulk RNA-seq] 24 samples shares crc
- GSE284139 Epithelial RXRα activity induced by Westernization of diet instigates enteritis in Crohn’s disease 19 samples shares rxr
- GSE277622 Transcriptomic profiling of LLC LeptoM vector control, Nr1h2/3 DKO and RXRa/b/g TKO upon stimulation with 1μM 9 cis-retinoic acid (RA) in vitro 17 samples shares rxr
- GSE280281 Vhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [scRNA-seq] 16 samples shares crc
- GSE271310 Role of RXRg in NSC-derived OPCs and their differentiation 16 samples shares rxr
- GSE290329 A Study of Allostery Within Liganded RARα:RXR Heterodimers at the Genome Scale [RNA-seq] 15 samples shares rxr
- GSE319754 RXRα Suppression Drives Hepatic Metabolic and Immune Dysfunction in Sepsis: Gene induction by BEX in Sham & CLP (8h) 12 samples shares rxr
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.